ThroughoutDiablo 4, players will encounter a range of challenges including various boss battles, each with their own quirks and patterns of attack players must watch out for. While progressing through the story, enemies will level alongside the player to ensure that each fight is fairly balanced. Nonetheless, some bosses can still be considerably more challenging than others due to the nature of their attacks and extended health bars.

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Each of these bosses will be encountered as part of the game’s main story, and players will have to defeat them to progress. Since defeating these bosses will advance the main campaign, it is only possible to take them on once with any given character, unlikeWorld Bosses, which can be faced multiple times.

8Lilith’s Lament

As the first major boss fight players are likely to experience inDiablo 4, Lilith’s Lament can be challenging for precisely that reason. Typically, players will not be at a very high level when facing this monstrous demonic entity, which will limit the damage they can inflict as well as their range of potential combat abilities. The encounter will occur during the quest “The Descent” towards the end of Act 1.

Primarily, Lilith’s Lament will utilize ranged shadow spells as well as a blood pool AoE ability. These attacks become relatively predictable and can be avoided so long as the player remains very mobile and agile for the duration of the battle. During the battle’s second phase, a large knight willcome to the player’s aidand can create a force field to protect the player from the Lament’s wave attack, which will cover the entire floor of the battle arena.

Diablo 4 Campaign Bosses Lilith’s Lament

7Eidolon Of Orbei

The Eidolon Of Orbei is a towering, ghostly shamanic type with some unique attacks that might take players by surprise. Encountered in Act 3 of the main story, during the quest “Suffering Disquiet” this boss uses traps and AoE abilities to attempt to limit space and close off any potential escape routes the player might have.

Chiefly, The Eidolon will deploy swirling red vortexes which will drain the player’s health and reduce vision if caught inside. In addition to this, he will summon Bone Walls that can be used to trap the player or as a potential shield for the boss himself. Players can attack and break through these walls, which almost serve as his “minions” given the regularity with which players will have to switch from attacking the boss to breaking down these walls. As his health is reduced, the frequency of these attacks will increase, so it is important to stay mobile and attempt to avoid being cornered or boxed in.

Diablo 4 Campaign Bosses Eidolon Of Orbei

6Brol, The Tyrant King

Brol, The Tyrant King is a large barbarian-type opponent wielding a sword in each hand and supported by lesser minions called Maniacs. Players will have to face Brol during Act 3 of the campaign as part of the “Descent Into Flame” quest. The battle will take place in a limited space surrounded by lava, so players can expect to have to frequently dodge attacks from Brol and his minions throughout the four stages of this boss battle.

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Brol’s main attacks are a standard charging attack and a ground-smashing attack, both of which can cause substantial damage. When his health is drained by a quarter, Brol will then summon Maniacs who fall from the ceiling and fight alongside him. Keys to victory lie in dodging Brol’s heavy attacks while dispatching the lesser enemies quickly to focus more damage output on the boss himself.

5Andariel

Andariel is one of the most iconic bosses inDiablo 4, making a return from series stapleDiablo 2.The Maiden of Anguish makes her appearance in Act 4 during the quest “Anguish Incarnate,” following a summoning ritual performed by Elias in Act 3. The fight takes place during a sandstorm, adding an extra element for players to be wary of since they can be damaged by the sandstorm as well.

Andariel uses Rune Chains to trap the player and much like the Eidolon of Oriel’s Bone Wall, players will have to break these downin addition to attacking the boss. She can also use projectiles and cast powerful red streaks across the ground that players must avoid. Once she breaks free from her chains, Andariel will also have additional melee attacks - but she can be vulnerable to staggering and is best attacked during this time.

Diablo 4 Campaign Bosses Brol

4Astaroth

Astaroth is an extremely menacing horned demon, summoned to Sanctuary by Lilith herself. Players will encounter him in Act 2 during the quest “As The World Burns.” Easily distinguished by his three-headed mount, the Amalgam of Rage, Astaroth is one of the most intimidating and unique bosses in the game.

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Defeating him will mainly require the playerto utilize a lot of dodging and striking from the rear. The key attacks to look out for include a very powerful staff swing which can take the player out sometimes with a singular blow, a fireball AoE attack, and Fire Breathing from the heads of the Amalgam of Rage. Fire-resistant gear is certainly recommended for this encounter, as well as any equipment that might reduce the cooldown time for the Evade mechanic.

3Elias

Elias is a powerful caster type and the summoner of Lilith. He is particularly challenging due to the fact that players will have to face him multiple times throughout the story as parts of Acts 3 and 5. The boss battles will take place during the quests “Piercing The Veil” (Act 3) and “On The Precipice” (Act 5).

During the first encounter, Elias will predominantly rely upon summoning minions, which can become overwhelming if players don’t carefully balance thinning them out and delivering damage to the boss. In Act 5, he will utilize a Crimson Ripple attack as well as using his previous attacks only with increased power. Ranged builds might find this boss easier than others as they will be more readily able to avoid his particular attack patterns.

Diablo 4 Andariel

2Duriel, Lord Of Pain

Duriel, Lord of Pain is a tough worm-like boss with one of the most grotesque appearances in the game. Appearing in Act 6 as part of the quest “The Walls Shake,” Duriel will be surrounded by smaller eggs that can hatch and act as minions, overwhelming the player if they are not careful.

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diablo 4 astaroth players demand replayable campaign bosses

Duriel can be challengingtoo due to the range of different attacking abilities the creature possesses. With a burrowing ability similar to teleportation as well as a ranged Belly Belch attack, nowhere is truly safe within the relatively compact battle arena where this fight takes place. Avoiding these attacks and striking from the rear is the best course of action, and using any AoE abilities to deal with the maggot swarm will certainly help too.

1Lilith

Diablo 4’s main antagonist Lilith, Mother of Sanctuary, should hardly need much introduction at this point.The ultimate battle with this menacing adversarywill finally take place in the final quest “What Lies Ahead.” It is recommended that players reach roughly level 50 before trying to take her on, as only at this level will players possess the requisite skill set for the battle.

Beginning in her “Creator of Sanctuary” form, Lilith will primarily rely on streaking ground attacks and powerful melee sweeps for the majority of her first phase. Once her health has been lowered, she will transform into her “Daughter of Hatred” form which becomes significantly more difficult. Another challenge in this battle is the fact that the battle arena will start to crumble away and reduce in size, leaving players with more danger and less room to avoid it. The key to defeating Lilith lies in unleashing as much damage as possible when she is staggered.

Diablo 4 Bosses Elias

Diablo 4is currently available on PC, PS4, PS5, Xbox One, and Xbox Series X/S.

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Diablo 4 Boss Duriel

Lilith in Diablo 4